Sex Reversal Gene: Male Mice Can Be Created Without Y Chromosome Via Ancient Brain Gene

ScienceDaily for December 22, 2010 reported on male mice created with two X-chromosomes.

However, Adelaide researchers have discovered a way of creating a male mouse without a Y chromosome by activating a single gene, called SOX3, in the developing fetus. SOX3 is known to be important for brain development but has not previously been shown to be capable of triggering the male pathway.